Custom software application: Public SDK libraries are available on GitHub for all integration into the users proprietary software, Adapted to cell culture or other experiments involving resistance variations: the algorithm adjusts its model to the setup resistance in real-time, Save precious sample or reagent: reduced time to reach desired flow rates uses less liquid during a calibration step, Save time with reduced settling time and no calibration. Each module is a separate and independent pressure channel. Complex pressure and flow distribution can be eliminated as the unit can be placed at the location where pressure, vacuum, or flow control is needed. Two pressure modules consisting of a 0 2000 mbar and -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Control without a PC using the Flow EZ hardware interface with one hand. Fluigent has developed (patent pending) an all-in-one, free standing, compact, integrated pressure-based control with an internal pressure supply technology. Support reservoir sizes from 2 mL to one liter laboratory bottles. All-in-one pressure controller and supply powered by battery or line voltage. Using a pressure leakage or a valve in complement to the pump is a way to circumvent this limitation. Reach your pressure targets rapidly and get your experiment started instantaneously. Configure your own system: The F-OEM consists of a main board to which one can add pressure and switch control modules depending on the configuration required. With the Flow EZ or Push-Pull modules one can precisely regulate and control pressure & vacuum, the LINK and LINK COM modules provide communication to a computer or any external instrument using TTL ports, USB cable or Serial port communication. ThePXmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution. The field-proven technology ensures to obtain quickly reliable and superior results for your experiments. It can have an integrated pressure/vacuum source or be coupled with the FLPG+, an external pressure source, for those who dont have access to a laboratory bench mounted gas source. Control and regulate pressure and flow rate without a PC using the LineUp hardware interface. is well-suited technology for applications that require mobile or compact fluidic control devices, including point of care (PoC) diagnostic and testing, or for water and soil on-site analysis. By providing two pressure sources (any vacuum or pressurefrom -800 to +2000 mbar), each module is able to deliver one of the two provided pressures through8 independent outlets. Control without a PC using the Push-Pull hardware interface with one hand. The technology consists of a uniquely engineered assembly of electronics, sensors integrated with a micropump, and pneumatics to provide high performance. Our LineUp product range is the next generation of microfluidic systems. Whether your application is with droplets, cell biology, particle studies, or in other research areas, we have the expertise and knowledge to provide the most cost-effective and technically advanced solutions for your fluid control needs. It is available for vacuum and pressures of up to 2 bar. Janire, S., Raquel, C.-C., R_oisn, M. O. No microfluidic valves. Inject and switch different flow paths. The entire system can be controlled without a PC using local control and can also be monitored by Fluigent Software to extend its capabilities and benefit from automation. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. Our F-OEM offers our highest performance, efficiency, and widest pressure and flow rate ranges to support the most demanding industrial applications, including microfluidic and nanofluidic applications (microchannels, nanochannels, capillaries, lab on a chip). In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. With the addition of a pressure leakage component, the pressure drop now takes about 5 seconds (see Fig. One can be operational and generate data rapidly. The pressure automatically adjusts in the background to maintain the flow rate. Prof. Jeroen Lammertyn, KU Leuven Belgium Biosensors group. Our engineered systems tackle these limitations by bringing a cost-effective solution with a highly reduced footprint. Fig 2: (left) Pneumatic schematic of a standard fluidic system using pressure to move fluids (right) Pneumatic schematic of Fluigent new technology. In addition, a microfluidic pressure pump can easily be integrated into a setup with the Software Development Kit (SDK). If you are seeking to replace high-precision syringe pumps or other conventional instruments, we offer modern microfluidic systems and components that enhance productivity.. The Adapt is used to connect Flow EZ modules with different pressure ranges without the need of additional pressure sources. The conception of a MFCS controller depends on your needs. It provides a dual interface USB and RS232 for high versatility in the integration. Pressurize up to 32 reservoirs simultaneously or independently. The pressure automatically adjusts in the background to maintain the set flow rate. Point of care devices needing a small footprint can have engineering challenges. Combined with Flow EZ and Push-Pull, set a versatile system for pressure-base microfluidic experiments. When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. When combined with theLINKmodule, the Flow EZcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, Key indicators to ensure long-term performance of your OEM flow control components, Things you should know when integrating fluidics into your system, DFC, self-learning flow rate control algorithm, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, Droplet generation using syringe pumps and pressure-based flow controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Pressure : 0 to 7000 mbar (101 psi) required pressure supply 7100 mbar (103 psi), Pressure: 0 to 2000 mbar (29 psi) required pressure supply 2100 mbar (30.4 psi) min, 2400 max, Pressure: 0 to 1000 mbar (14.5 psi) required pressure supply 1100 mbar (16 psi) min, 1300 max, Pressure: 0 to 345 mbar (5 psi) required pressure supply 1100 mbar (16 psi) (600 min, 1300 max), Pressure: 0 to 69 mbar (0.9 psi) required pressure supply 150 mbar (2.18 psi), Pressure: 0 to 25 mbar (0.36 psi) required pressure supply 150 mbar (2.18 psi), Vacuum : -25 mbar (-0.36 psi) / -69 mbar (-0.9 psi) / -345 mbar (-5 psi) / -800 mbar required vacuum -800 mbar (-11.6 psi), Push-Pull : -800 mbar (-11.6 psi) to 1000 mbar (14.5 psi) required pressure 1100 mbar (16 psi) min and 1300 max and vacuum -800 mbar (-11.6 psi) (min), 0.1% of full scale CV (on measured values), Liquid flow rate sensor input, customizable to work with third party sensors (through SDK), Control up to 4 x switches or valves per module compatible with Fluigent 2 position switches and rotary valves (M-switch, L-switch, 2-switch), Pressurized or bottled clean dry and non-corrosive or explosive gas (Ambient air, N2, Ar, CO2) (02 could be a thing, need to check), OD 4mm female push in fitting (on standard version, can be fittingless, then it is an M5 thread), >1W groundable for F-OEM platform (can be increased depending on peripherals, eg pump, fans etc) 6W maximum per FEZ module, 48W maximum per SWEZ module (rotary valves ~ 12W), External power, 2A or 7A available from standard, but custom can be accepted using MBPT terminal block connection, USB (standard board), RS232 (alternative board) + other protocols on demand, RJ45 female (or 2wire terminal block for SWEZ lite), 0-24VDC, digital controlled output 5 or 24 volts selectable, 2 x USB2.0 ports (available only on the USB connection protocol version, 0.1 Kg (F-OEM platform), 0.4 Kg (per pressure module with manifold), 0.3 kg (per switch module), Main electronic board. We provide instrument development industrial engineers with the right liquid handling solution for your system. What I like most is that you are independent of a computer and can directly control both positive and negative pressure.. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Explore our 15 years of field-proven experience, Developing a new fluidic system? Continuous monitoring of water resources such as freshwater, seawater, and, in particular, wastewater and drinking water, for human and animal consumption, is essential2. We have a large range of flow sensors ranging from 0-1.5 L/min to 0-5 mL/min. It provides the best response time, pulseless, and highly stable flow conditions for high precision industrial microfluidic applications. These often require more bulky equipment as the internal technology is more advanced. It can support a wide range of connections (Wi-Fi, BLE, IoT, USB, industrial bus), and embedded protocols. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. The module can be used to multiply the channel output number in the LineUp system or any other pressure system. It allows optimal flow control with the reliability required for demanding industrial environments. The PX module is a CE and RoHS compliant single controller available in 3 pressure ranges. Point of Care (PoC) testing allows one to diagnose diseases at or near the patient site. Plug directly the sensor to the PC and benefit from a compact solution for pressure detection. However, adding such leakage components influence the overall performance: the maximum pressure that can be reached has now decreased of about 15% (from 375 mbar to 310 mbar illustrated in the graph Fig. When combined with theLINKmodule, thePush-Pullcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). The PRESSURE UNIT product line allow for the accurate measurement of pressure and vaccum within the range -1000 mbar to 7 bar. Fluigents i (patent pending) powerful pressure regulation algorithm is based on physical equations and self-learning routines that offer several benefits: By directly connecting a flow rate sensor, it is possible to monitor or control flow rate in real time. This allows to perform operations that require fast response time, or require fast change between applied positive pressure and vacuum. The MFCS can be controlled by Fluigent software to automate your protocols. The flow generated can be measured or controlled with FLOW UNITs and the Flowboard. Combine up to 12 modules as your work flow grows. The F-OEM makes use of the best combination of pneumatic, mechanical, and electrical elements associated with our new generation algorithm: Fluigent Direct Flow-rate Control (DFC) a self-learning algorithm that performs continuous adjustment over the algorithm parameters based on the actual response time. A switch module is also directly connected to the F-OEM main board, allowing for connecting a bidirectional 11-port / 10-way microfluidic valve for injection or selection of up to 10 different fluids (Fluigent M-X). The addition of aflow sensorenables one tocontrol or monitor flow rateas well asdispense volume. When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. The pressure automatically adjusts in the background to maintain the set flow rate. As an alternative, microfluidic-based portable devices have been developed for on-site analysis. It provides flexibility without compromising performance (accuracy and response time). Mixed pressure ranges can be connected to the same board (positive and negative pressures, and Push-Pull). For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics. It is well established that pressure-based flow control offers unequaled flow stability and response times. Front. To ensure excellent response time while guaranteeing the best performance, Fluigent developed a technology that makes use of proportional valves. The product line can detect values over the range of-1000 mbar(-15 psi) to7000 mbar(100 psi). The device is well designed and allows for easy control of my microfluidic chips. Each P-SWITCH module requires 2 supplied sources overthe range or -800 mbar to 2 bar. Single gateway for industrial-grade microfluidic control: The platform can be used to control a pressure source and power other third-party devices required in the microfluidic system. The applied pressure will automatically adjust to maintain the flow rate. Although an external pressure supply allows working over large pressure ranges (generally up to 7 bar) and high gas flow rates, it can be cumbersome, and integration into a device is challenging. Based on the patented FASTABTM technology, our pressure and flow controllers ensure a stable and pulseless flow to enhance accuracy and reproducibility in the experiments. 8, 114 (2021). When connected to a computer, one can use our Fluigent software tobenefit from automationorlive monitoring and recording of data. Bioeng. No switch modules. Use the P-SWITCH buttons to quickly commute outlets between the two supplied pressure(s)/vacuum(s) and focus on the experiment. Either 4 or 8 channels are available with different pressure ranges for microfluidic experiments. 5 that compares Fluigent solution with a standalone gas micropump. In the base configuration, the system controls pressure, and the liquid flow is a function of system resistance, fluid viscosity, etc. Control and handle the fluid on the chip without additional tubing. A photonic technology institute tests a variety of lab-on-chip systems, the number of flow channels and the required pressures vary from one test to another. Explore Fluigent industrial. The FLUIGENT PX pressure controller is a single, miniaturized electronic pressure controller with an integrated and intelligent feedback loop for highest performance. Weighing in less than 170 g and with a volume of 140 cm3, Excellent stability and response time thanks to Fluigent pressure and liquid handling expertise. Fig 1: (left) A pressure supply and pressure controller vs our new technology (right) Fluigent engineered technology. The use of pressure to handle fluids also provides a quick response time allowing for precise operations such as stop flow and accurate pressure/flow rate steps. Liquid flow rate ranges from a few nL/min to 5 mL/min. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. The MFCSTM series and Flow EZTM with Fluigent valves can be used for automated cell perfusion as in the next video. The Flow EZmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution. Its improved reactivity allows countering, in real-time, the interactions between microfluidic channels in complex situations. Select modules you need and combine them together. Flow sensors are connected for flow rate monitoring and control. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. The F-OEM makes use of Fluigents patented Fastab 2 technology. The set-up allows us to further advance our research in both continuous flow and droplet microfluidics.. The Flow EZ integrates the all-new DFC (Direct Flow Control) algorithm. In fact, it is possible to observe that the micropump will take more than a minute to reach zero pressure. Combine as many modules as you want to fit your application needs. 1186, (2021). The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. The pressure controllers immediately provide the requested pressures with very high stability thanks to the feedback loop. Fluigent pressure and flow controllers bring this performance and benefits to the system. The applied pressure will automatically adjust to maintain the flow rate. These can easily be joined together tomatch all application requirementsor reconfigure the system for a new experimental design. The F-OEM range of modules allows for regulation of vacuum/pressure down to -800 mbar and up to 7 bar, with the possibility to use a push-pull module (-800 / +1 000 mbar). This allows the user to set a flow rate directly on the instrument display. The technology used in this pressure pumpavoids cross contaminationbecause liquids only contact air. The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. Fluigent was the first company to introduce pressure-based flow control to handle fluids in microfluidics. 1. Fluigents unique broad range of solutions for use in microfluidic and nanofluidics applications ensure full control of flow rates with a greater control, automation, precision, ease of use and also minimize contamination. The PX Pressure-driven flow control simplifies fluid management even for multiple fluids, and reduces the time needed to add or remove channels. Point of care tests such as blood analysis, glucose monitoring, infectious disease testing, cholesterol testing, or cardiac markers are marketed1. The technology used in this pressure pumpavoids cross-contaminationbecause liquids only contact air. See an example of applications using the MFCS series: Separation of parasites from human blood using deterministic lateral displacement, S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Lab Chip, vol.11, 2011. Output pressures, flow rate, and valves can be controlled by using OxyGEN Fluigent software, or our Software Development Kit (SDK) for custom software applications. The LineUp series module can be combined together to add pressure/vacuum channels, valve control and turn one channel into 8 independent outlets using the P-SWITCH. Improved reliability and reproducibility of of results is possible due to the pulseless flow. Most pressure controllers require a pressure source which is regulated. Fluigent is an international company which develops, manufactures and supports the most advanced fluid control systems available for microfluidics offering greater control, automation, precision, and ease of use.. 3 pressure modules consisting of two 0 2000 mbar and a -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Combined with a FLOW UNIT it allows for direct control of flow rate. It can be used without a PC or controlled with Fluigent Software Solutions to benefit from control in real-time, protocol automation, graphic displays and custom integration.
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